Fusion Protein Anchored onto Tumor Cells Superantigen- Transmembrane Sequence Antitumor Response Elicited by a
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Antitumor response elicited by a superantigen-transmembrane sequence fusion protein anchored onto tumor cells.
Superantigens stimulate T cells bearing certain TCR beta-chain variable regions when bound to MHC II molecules. We investigated whether the superantigen toxic shock syndrome toxin-1 (TSST1) could induce an antitumor immune response when anchored onto MHC II-negative tumor cells. Our approach was to facilitate association of TSST1 with cell membranes by fusing its coding region to the transmembr...
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